SuicidDentistV1, Main, Exploration, bibRecord, 000145

PNIPAAM modified mesoporous hydroxyapatite for sustained osteogenic drug release and promoting cell attachment.

Identifieur interne : 000145 ( Main/Exploration ); précédent : 000144; suivant : 000146

PNIPAAM modified mesoporous hydroxyapatite for sustained osteogenic drug release and promoting cell attachment.

Auteurs : Tao Wu [République populaire de Chine] ; Lei Tan [République populaire de Chine] ; Ning Cheng [République populaire de Chine] ; Qi Yan [République populaire de Chine] ; Yu-Feng Zhang [République populaire de Chine] ; Chuan-Jun Liu [République populaire de Chine] ; Bin Shi [République populaire de Chine]

Source :

Materials science & engineering. C, Materials for biological applications [ 1873-0191 ] ; 2016.

RBID : pubmed:26952496

Descripteurs français

English descriptors

KwdEn :
- Acrylic Resins (chemistry), Alkaline Phosphatase (metabolism), Animals (MeSH), Anticholesteremic Agents (chemistry), Anticholesteremic Agents (metabolism), Bone Marrow Cells (cytology), Cell Adhesion (drug effects), Cell Differentiation (drug effects), Cell Proliferation (drug effects), Cell Survival (drug effects), Cells, Cultured (MeSH), Drug Carriers (chemistry), Drug Carriers (toxicity), Drug Liberation (MeSH), Durapatite (chemical synthesis), Durapatite (chemistry), Female (MeSH), Mesenchymal Stem Cells (cytology), Mesenchymal Stem Cells (drug effects), Mesenchymal Stem Cells (metabolism), Microscopy, Fluorescence (MeSH), Osteogenesis (drug effects), Porosity (MeSH), Rats (MeSH), Rats, Wistar (MeSH), Simvastatin (chemistry), Simvastatin (metabolism), Spectroscopy, Fourier Transform Infrared (MeSH), X-Ray Diffraction (MeSH).
MESH :
- chemical , chemical synthesis : Durapatite.
- chemical , chemistry : Acrylic Resins, Anticholesteremic Agents, Drug Carriers, Durapatite, Simvastatin.
- chemical , metabolism : Alkaline Phosphatase, Anticholesteremic Agents, Simvastatin.
- cytology : Bone Marrow Cells, Mesenchymal Stem Cells.
- drug effects : Cell Adhesion, Cell Differentiation, Cell Proliferation, Cell Survival, Mesenchymal Stem Cells, Osteogenesis.
- metabolism : Mesenchymal Stem Cells.
- chemical , toxicity : Drug Carriers.
- Animals, Cells, Cultured, Drug Liberation, Female, Microscopy, Fluorescence, Porosity, Rats, Rats, Wistar, Spectroscopy, Fourier Transform Infrared, X-Ray Diffraction.

Abstract

This work presented a sustained release system of simvastatin (SIM) based on the mesoporous hydroxyapatite (MHA) capped with poly(N-isopropylacrylamide) (PNIPAAM). The MHA was prepared by using cetyltrimethylammonium bromide (CTAB) as a template and the modified PNIPAAM layer on the surface of MHA was fabricated through surface-initiated atom transfer radical polymerization (SI-ATRP). The SIM loaded MHA-PNIPAAM showed a sustained release of SIM at 37 °C over 16 days. The bone marrow mesenchymal stem cell (BMSC) proliferation was assessed by cell counting kit-8 (CCK-8) assay, and the osteogenic differentiation was evaluated by alkaline phosphatase (ALP) activity and Alizarin Red staining. The release profile showed that the release of SIM from MHA-SIM-PNIPAAM lasted 16 days and the cumulative amount of released SIM was almost seven-fold than MHA-SIM. Besides, SIM loaded MHA-PNIPAAM exhibited better performance on cell proliferation, ALP activity, and calcium deposition than pure MHA due to the sustained release of SIM. The quantity of ALP in MHA-SIM-PNIPAAM group was more than two fold than pure MHA group at 7 days. Compared to pure MHA, better BMSC attachment on PNIPAAM modified MHA was observed using fluorescent microscopy, indicating the better biocompatibility of MHA-PNIPAAM.

DOI: 10.1016/j.msec.2016.01.012
PubMed: 26952496
PubMed Central: PMC5995466

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000147
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Le document en format XML

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<author><name sortKey="Liu, Chuan Jun" sort="Liu, Chuan Jun" uniqKey="Liu C" first="Chuan-Jun" last="Liu">Chuan-Jun Liu</name>
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<author><name sortKey="Shi, Bin" sort="Shi, Bin" uniqKey="Shi B" first="Bin" last="Shi">Bin Shi</name>
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<term>Alkaline Phosphatase (metabolism)</term>
<term>Animals (MeSH)</term>
<term>Anticholesteremic Agents (chemistry)</term>
<term>Anticholesteremic Agents (metabolism)</term>
<term>Bone Marrow Cells (cytology)</term>
<term>Cell Adhesion (drug effects)</term>
<term>Cell Differentiation (drug effects)</term>
<term>Cell Proliferation (drug effects)</term>
<term>Cell Survival (drug effects)</term>
<term>Cells, Cultured (MeSH)</term>
<term>Drug Carriers (chemistry)</term>
<term>Drug Carriers (toxicity)</term>
<term>Drug Liberation (MeSH)</term>
<term>Durapatite (chemical synthesis)</term>
<term>Durapatite (chemistry)</term>
<term>Female (MeSH)</term>
<term>Mesenchymal Stem Cells (cytology)</term>
<term>Mesenchymal Stem Cells (drug effects)</term>
<term>Mesenchymal Stem Cells (metabolism)</term>
<term>Microscopy, Fluorescence (MeSH)</term>
<term>Osteogenesis (drug effects)</term>
<term>Porosity (MeSH)</term>
<term>Rats (MeSH)</term>
<term>Rats, Wistar (MeSH)</term>
<term>Simvastatin (chemistry)</term>
<term>Simvastatin (metabolism)</term>
<term>Spectroscopy, Fourier Transform Infrared (MeSH)</term>
<term>X-Ray Diffraction (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adhérence cellulaire (effets des médicaments et des substances chimiques)</term>
<term>Animaux (MeSH)</term>
<term>Anticholestérolémiants (composition chimique)</term>
<term>Anticholestérolémiants (métabolisme)</term>
<term>Cellules cultivées (MeSH)</term>
<term>Cellules de la moelle osseuse (cytologie)</term>
<term>Cellules souches mésenchymateuses (cytologie)</term>
<term>Cellules souches mésenchymateuses (effets des médicaments et des substances chimiques)</term>
<term>Cellules souches mésenchymateuses (métabolisme)</term>
<term>Diffraction des rayons X (MeSH)</term>
<term>Différenciation cellulaire (effets des médicaments et des substances chimiques)</term>
<term>Durapatite (composition chimique)</term>
<term>Durapatite (synthèse chimique)</term>
<term>Femelle (MeSH)</term>
<term>Libération de médicament (MeSH)</term>
<term>Microscopie de fluorescence (MeSH)</term>
<term>Ostéogenèse (effets des médicaments et des substances chimiques)</term>
<term>Phosphatase alcaline (métabolisme)</term>
<term>Porosité (MeSH)</term>
<term>Prolifération cellulaire (effets des médicaments et des substances chimiques)</term>
<term>Rat Wistar (MeSH)</term>
<term>Rats (MeSH)</term>
<term>Résines acryliques (composition chimique)</term>
<term>Simvastatine (composition chimique)</term>
<term>Simvastatine (métabolisme)</term>
<term>Spectroscopie infrarouge à transformée de Fourier (MeSH)</term>
<term>Survie cellulaire (effets des médicaments et des substances chimiques)</term>
<term>Vecteurs de médicaments (composition chimique)</term>
<term>Vecteurs de médicaments (toxicité)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Durapatite</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Acrylic Resins</term>
<term>Anticholesteremic Agents</term>
<term>Drug Carriers</term>
<term>Durapatite</term>
<term>Simvastatin</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Alkaline Phosphatase</term>
<term>Anticholesteremic Agents</term>
<term>Simvastatin</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Anticholestérolémiants</term>
<term>Durapatite</term>
<term>Résines acryliques</term>
<term>Simvastatine</term>
<term>Vecteurs de médicaments</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules de la moelle osseuse</term>
<term>Cellules souches mésenchymateuses</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Bone Marrow Cells</term>
<term>Mesenchymal Stem Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Adhesion</term>
<term>Cell Differentiation</term>
<term>Cell Proliferation</term>
<term>Cell Survival</term>
<term>Mesenchymal Stem Cells</term>
<term>Osteogenesis</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Adhérence cellulaire</term>
<term>Cellules souches mésenchymateuses</term>
<term>Différenciation cellulaire</term>
<term>Ostéogenèse</term>
<term>Prolifération cellulaire</term>
<term>Survie cellulaire</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Mesenchymal Stem Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Anticholestérolémiants</term>
<term>Cellules souches mésenchymateuses</term>
<term>Phosphatase alcaline</term>
<term>Simvastatine</term>
</keywords>
<keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>Durapatite</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Drug Carriers</term>
</keywords>
<keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Vecteurs de médicaments</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cells, Cultured</term>
<term>Drug Liberation</term>
<term>Female</term>
<term>Microscopy, Fluorescence</term>
<term>Porosity</term>
<term>Rats</term>
<term>Rats, Wistar</term>
<term>Spectroscopy, Fourier Transform Infrared</term>
<term>X-Ray Diffraction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules cultivées</term>
<term>Diffraction des rayons X</term>
<term>Femelle</term>
<term>Libération de médicament</term>
<term>Microscopie de fluorescence</term>
<term>Porosité</term>
<term>Rat Wistar</term>
<term>Rats</term>
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<front><div type="abstract" xml:lang="en">This work presented a sustained release system of simvastatin (SIM) based on the mesoporous hydroxyapatite (MHA) capped with poly(N-isopropylacrylamide) (PNIPAAM). The MHA was prepared by using cetyltrimethylammonium bromide (CTAB) as a template and the modified PNIPAAM layer on the surface of MHA was fabricated through surface-initiated atom transfer radical polymerization (SI-ATRP). The SIM loaded MHA-PNIPAAM showed a sustained release of SIM at 37 °C over 16 days. The bone marrow mesenchymal stem cell (BMSC) proliferation was assessed by cell counting kit-8 (CCK-8) assay, and the osteogenic differentiation was evaluated by alkaline phosphatase (ALP) activity and Alizarin Red staining. The release profile showed that the release of SIM from MHA-SIM-PNIPAAM lasted 16 days and the cumulative amount of released SIM was almost seven-fold than MHA-SIM. Besides, SIM loaded MHA-PNIPAAM exhibited better performance on cell proliferation, ALP activity, and calcium deposition than pure MHA due to the sustained release of SIM. The quantity of ALP in MHA-SIM-PNIPAAM group was more than two fold than pure MHA group at 7 days. Compared to pure MHA, better BMSC attachment on PNIPAAM modified MHA was observed using fluorescent microscopy, indicating the better biocompatibility of MHA-PNIPAAM.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26952496</PMID>
<DateCompleted><Year>2016</Year>
<Month>12</Month>
<Day>13</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>12</Month>
<Day>02</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-0191</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>62</Volume>
<PubDate><Year>2016</Year>
<Month>May</Month>
</PubDate>
</JournalIssue>
<Title>Materials science & engineering. C, Materials for biological applications</Title>
<ISOAbbreviation>Mater Sci Eng C Mater Biol Appl</ISOAbbreviation>
</Journal>
<ArticleTitle>PNIPAAM modified mesoporous hydroxyapatite for sustained osteogenic drug release and promoting cell attachment.</ArticleTitle>
<Pagination><MedlinePgn>888-96</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.msec.2016.01.012</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S0928-4931(16)30012-1</ELocationID>
<Abstract><AbstractText>This work presented a sustained release system of simvastatin (SIM) based on the mesoporous hydroxyapatite (MHA) capped with poly(N-isopropylacrylamide) (PNIPAAM). The MHA was prepared by using cetyltrimethylammonium bromide (CTAB) as a template and the modified PNIPAAM layer on the surface of MHA was fabricated through surface-initiated atom transfer radical polymerization (SI-ATRP). The SIM loaded MHA-PNIPAAM showed a sustained release of SIM at 37 °C over 16 days. The bone marrow mesenchymal stem cell (BMSC) proliferation was assessed by cell counting kit-8 (CCK-8) assay, and the osteogenic differentiation was evaluated by alkaline phosphatase (ALP) activity and Alizarin Red staining. The release profile showed that the release of SIM from MHA-SIM-PNIPAAM lasted 16 days and the cumulative amount of released SIM was almost seven-fold than MHA-SIM. Besides, SIM loaded MHA-PNIPAAM exhibited better performance on cell proliferation, ALP activity, and calcium deposition than pure MHA due to the sustained release of SIM. The quantity of ALP in MHA-SIM-PNIPAAM group was more than two fold than pure MHA group at 7 days. Compared to pure MHA, better BMSC attachment on PNIPAAM modified MHA was observed using fluorescent microscopy, indicating the better biocompatibility of MHA-PNIPAAM.</AbstractText>
<CopyrightInformation>Copyright © 2016 Elsevier B.V. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wu</LastName>
<ForeName>Tao</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan 430079, PR China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tan</LastName>
<ForeName>Lei</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072, PR China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cheng</LastName>
<ForeName>Ning</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan 430079, PR China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yan</LastName>
<ForeName>Qi</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan 430079, PR China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Yu-Feng</ForeName>
<Initials>YF</Initials>
<AffiliationInfo><Affiliation>The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan 430079, PR China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Chuan-Jun</ForeName>
<Initials>CJ</Initials>
<AffiliationInfo><Affiliation>Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072, PR China. Electronic address: cjliu@whu.edu.cn.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shi</LastName>
<ForeName>Bin</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan 430079, PR China. Electronic address: shibin_dentist@126.com.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>F99 CA223019</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>01</Month>
<Day>08</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>Mater Sci Eng C Mater Biol Appl</MedlineTA>
<NlmUniqueID>101484109</NlmUniqueID>
<ISSNLinking>0928-4931</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000180">Acrylic Resins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000924">Anticholesteremic Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D004337">Drug Carriers</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>25189-55-3</RegistryNumber>
<NameOfSubstance UI="C052970">poly-N-isopropylacrylamide</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>91D9GV0Z28</RegistryNumber>
<NameOfSubstance UI="D017886">Durapatite</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>AGG2FN16EV</RegistryNumber>
<NameOfSubstance UI="D019821">Simvastatin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.1.3.1</RegistryNumber>
<NameOfSubstance UI="D000469">Alkaline Phosphatase</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000180" MajorTopicYN="N">Acrylic Resins</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000469" MajorTopicYN="N">Alkaline Phosphatase</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000924" MajorTopicYN="N">Anticholesteremic Agents</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001854" MajorTopicYN="N">Bone Marrow Cells</DescriptorName>
<QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002448" MajorTopicYN="N">Cell Adhesion</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002454" MajorTopicYN="N">Cell Differentiation</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002470" MajorTopicYN="N">Cell Survival</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004337" MajorTopicYN="N">Drug Carriers</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D065546" MajorTopicYN="N">Drug Liberation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017886" MajorTopicYN="N">Durapatite</DescriptorName>
<QualifierName UI="Q000138" MajorTopicYN="N">chemical synthesis</QualifierName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D059630" MajorTopicYN="N">Mesenchymal Stem Cells</DescriptorName>
<QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008856" MajorTopicYN="N">Microscopy, Fluorescence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010012" MajorTopicYN="N">Osteogenesis</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016062" MajorTopicYN="N">Porosity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017208" MajorTopicYN="N">Rats, Wistar</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019821" MajorTopicYN="N">Simvastatin</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017550" MajorTopicYN="N">Spectroscopy, Fourier Transform Infrared</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014961" MajorTopicYN="N">X-Ray Diffraction</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">BMSCs</Keyword>
<Keyword MajorTopicYN="N">Bone</Keyword>
<Keyword MajorTopicYN="N">Mesoporous hydroxyapatite</Keyword>
<Keyword MajorTopicYN="N">PNIPAAM</Keyword>
<Keyword MajorTopicYN="N">Simvastatin</Keyword>
</KeywordList>
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<Month>12</Month>
<Day>22</Day>
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<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>01</Month>
<Day>05</Day>
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<affiliations><list><country><li>République populaire de Chine</li>
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<name sortKey="Cheng, Ning" sort="Cheng, Ning" uniqKey="Cheng N" first="Ning" last="Cheng">Ning Cheng</name>
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<name sortKey="Shi, Bin" sort="Shi, Bin" uniqKey="Shi B" first="Bin" last="Shi">Bin Shi</name>
<name sortKey="Tan, Lei" sort="Tan, Lei" uniqKey="Tan L" first="Lei" last="Tan">Lei Tan</name>
<name sortKey="Yan, Qi" sort="Yan, Qi" uniqKey="Yan Q" first="Qi" last="Yan">Qi Yan</name>
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   |clé=     pubmed:26952496
   |texte=   PNIPAAM modified mesoporous hydroxyapatite for sustained osteogenic drug release and promoting cell attachment.
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	Serveur d'exploration sur le suicide chez les dentistes
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Serveur d'exploration sur le suicide chez les dentistes

PNIPAAM modified mesoporous hydroxyapatite for sustained osteogenic drug release and promoting cell attachment.

PNIPAAM modified mesoporous hydroxyapatite for sustained osteogenic drug release and promoting cell attachment.

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